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Second approach will be better in case of presence of heterogeneity in the subjects. Heterogeneity may be in terms of skin types, colour, texture or it can be in terms of Age and sex which might affect the results if first approach is used. Comparing two subjects of different age, sex or skin type will in itself give different results. Thus in this case second approach is better, in which subjects are homogenous, since two sides of a face are used to compare the treatment.
First approach might have been used because of availability of a large sample which might have been of homogeneous i.e. the subjects might have had the similar characteristics. Or it might not have been possible to administer two different treatments on two sides of a face.
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