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Critical appraisal of non-communicable disease aetiology: Diabetes

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The overall objective for this assignment is to select a journal article relating to a non-communicable disease outcome in order to summarise the putative aetiological mechanism of the outcome, assess the evidence-base for the association, and to consider methodological limitations in the interpretation of the association. Question 1: Provide the reference of the article and indicate the following: The life-course model illustrated, and the period in the life-course to which the exposure relates. Summarise the hypothesized aetiological mechanism by which the exposure is associated with the out...

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Question Preview:
The overall objective for this assignment is to select a journal article relating to a non-communicable disease outcome in order to summarise the putative aetiological mechanism of the outcome, assess the evidence-base for the association, and to consider methodological limitations in the interpretation of the association. Question 1: Provide the reference of the article and indicate the following: The life-course model illustrated, and the period in the life-course to which the exposure relates. Summarise the hypothesized aetiological mechanism by which the exposure is associated with the outcome, Summarise the findings of the example article you selected. Question 2: Summarise the evidence-base that supports or does not support the association in the article you selected.Question 3: Summarise the key methodological limitations in interpreting the association described in Question 1, and assess the extent to which the observed association can be attributed to non-causal mechanisms.

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Type 2 diabetes mellitus primarily occurs due to genetics and lifestyle factors. The factors area sedentary lifestyle, inactivity, generous alcohol consumption, and cigarette smoking. Obesity is considered to be contributing to approximately 55 percent of type 2 DM cases. The increased childhood obesity rate between the 1960s and 2000s has led to the rise in type 2DM in adolescents and children. There is a strong genetic inheritable connection because a relative having type 2 DM can increase the risk of developing the diseases in others(Olokoba, Obateru & Olokoba, 2012). A weak correlation can be found between the concentrations in the constituent of plastics, incidences of type 2DM and urine of bisphenol

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