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## Question 1 [Total 10 marks] Note: This question does not require Stata. Table 1.1 below gives the results for two randomised controlled trials comparing oral ibuprofen versus placebo in children suffe

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Question 1 [Total 10 marks] Note: This question does not require Stata. Table 1.1 below gives the results for two randomised controlled trials comparing oral ibuprofen versus placebo in children suffering from a migraine. The outcome measure was pain relief at two hours following administration of oral ibuprofen or placebo. A change (increase or decrease) in the risk ratio (oral ibuprofen / placebo) of 10% or more is clinically important. Table 1.1 Trial n per group Ratio of sample proportions (oral ibuprofen / placebo) 95% confidence interval for ratio of population proportions ...

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## Solution Preview

a) For Trial 2: Ratio of sample proportions = 1.53
95% CI for population proportion = (p1-p0) +/- 1.96*Se(p1-p0)
= 0.4545-0.29697 +/- 1.96*se*p1-p0)

Se(p1) = sqrt[(0.4545*(1-0.4545)/165] = 0.038764
Se(p0) = sqrt[(0.2969*(1-0.2969)/165]= 0.035571

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